Downregulation of YAP in Clear Cell Renal Cell Carcinoma Contributes to Poor Prognosis and Progressive Features.

Abstract

THE GOAL:

To investigate the expression of Yes-associated protein (YAP) in clear cell renal cell carcinoma (ccRCC) and its clinical/prognostic significance.

PROCEDURES:

The expression of YAP protein was evaluated in tissue microarray by immunohistochemistry. Correlation between YAP expression and clinicopathological characteristics of renal cell carcinoma was analyzed.

RESULTS:

Downregulation of YAP protein was observed in ccRCC samples (P=0.0311). Downregulation of YAP expression was correlated with higher T classification, higher clinical stage, and poorer differentiation (P<0.05).

CONCLUSIONS:

Downregulation of YAP in clear cell renal cell carcinoma (ccRCC) may contribute to poor prognosis and progressive features.

• Authors: Xiaoyong Hu, Jie Chen, Qiang Fu
• Journal: Annals of clinical and laboratory science (Ann Clin Lab Sci) Vol. 47 Issue 1 Pg. 36-39 (Jan 2017) ISSN: 1550-8080 [Electronic] United States
• PMID: 28249914 (Publication Type: Journal Article)
• Copyright: © 2017 by the Association of Clinical Scientists, Inc.

Chemical References

• Adaptor Proteins, Signal Transducing
• Phosphoproteins
• Transcription Factors
• YAP-Signaling Proteins
• YAP1 protein, human

Topics

• Adaptor Proteins, Signal Transducing (metabolism)
• Carcinoma, Renal Cell (metabolism, pathology)
• Disease Progression
• Down-Regulation
• Female
• Humans
• Immunohistochemistry
• Kidney Neoplasms (metabolism, pathology)
• Male
• Middle Aged
• Phosphoproteins (metabolism)
• Prognosis
• Transcription Factors
• YAP-Signaling Proteins