Abstract | PURPOSE: METHODS: This single-blind randomized controlled trial was conducted on patients with traumatic ICH (with less than 30 ml) referring to the emergency department of Vali-Asr Hospital, Arak, Iran in 2014. Patients, based on the inclusion and exclusion criteria, were divided into intervention and control groups (40 patients each). All patients received a conservative treatment for ICH, as well as either intravenous TA or placebo. The extent of ICH growth as the primary outcome was measured by brain CT scan after 48 h. RESULTS: Although brain CT scan showed a significant increase in hemorrhage volume in both groups after 48 h, it was significantly less in the TA group than in the control group (p = 0.04). The mean total hemorrhage expansion was (1.7 ± 9.7) ml and (4.3 ± 12.9) ml in TA and placebo groups, respectively (p < 0.001). CONCLUSION: It has been established that TA, as an effective hospital-based treatment for acute TBI, could reduce ICH growth. Larger studies are needed to compare the effectiveness of different doses.
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Authors | Abolfazl Jokar, Koorosh Ahmadi, Tayyebeh Salehi, Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar |
Journal | Chinese journal of traumatology = Zhonghua chuang shang za zhi
(Chin J Traumatol)
Vol. 20
Issue 1
Pg. 49-51
(Feb 2017)
ISSN: 1008-1275 [Print] China |
PMID | 28209450
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2017 Daping Hospital and the Research Institute of Surgery of the Third Military Medical University. Production and hosting by Elsevier B.V. All rights reserved. |
Chemical References |
- Antifibrinolytic Agents
- Tranexamic Acid
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Topics |
- Adult
- Antifibrinolytic Agents
(therapeutic use)
- Brain Injuries, Traumatic
(diagnostic imaging, drug therapy)
- Cerebral Hemorrhage, Traumatic
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Single-Blind Method
- Tomography, X-Ray Computed
- Tranexamic Acid
(therapeutic use)
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