Oxaliplatin and Infliximab Combination Synergizes in Inducing Colon Cancer Regression.

Abstract

BACKGROUND Colon cancer is one of the most common malignant cancers and causes millions of deaths each year. There are still no effective treatments for colon cancer patients who are at advanced stage. Tumor necrosis factor-alpha (TNF-α) might be a good therapy target due to its widely-accepted roles in regulating multiple important biological processes, especially in promoting inflammation. MATERIAL AND METHODS We evaluated the expression of TNF-α in 108 human colon cancer tissue samples and 2 colon cancer cell lines (CT26 and HCT116), and analyzed its prognostic values. Further, we explored the roles and mechanism of anti-TNF-α treatment in combination with chemotherapy in vitro and in vivo. RESULTS We found that TNF-α was highly expressed in colon cancer cell lines. The survival analysis and Cox regression analysis indicated that high TNF-α was an independent adverse prognosticator of colon cancer. In addition, anti-TNF-α treatment enhanced the effects of chemotherapy in the xenograft mouse model through inducing ADCC and CDC effects. CONCLUSIONS We conclude that TNF-α is an independent adverse prognosticator of colon cancer, and anti-TNF-α might benefit colon cancer patients.

• Authors: Wenya Li, Jian Xu, Jian Zhao, Rui Zhang
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 23 Pg. 780-789 (Feb 12 2017) ISSN: 1643-3750 [Electronic] United States
• PMID: 28190020 (Publication Type: Journal Article)

Chemical References

• Organoplatinum Compounds
• Tumor Necrosis Factor-alpha
• Oxaliplatin
• Infliximab

Topics

• Animals
• Antineoplastic Combined Chemotherapy Protocols (pharmacology)
• Apoptosis (drug effects)
• Cell Line, Tumor
• Colonic Neoplasms (drug therapy, metabolism, pathology)
• Drug Synergism
• Female
• HCT116 Cells
• Humans
• Infliximab (administration & dosage, pharmacology)
• Male
• Mice
• Mice, Inbred BALB C
• Organoplatinum Compounds (administration & dosage, pharmacology)
• Oxaliplatin
• Prognosis
• Tumor Necrosis Factor-alpha (metabolism)
• Xenograft Model Antitumor Assays