Abstract | AIM: The purpose of the study was to assess the effect of Acoustic Radiation Force Impulse (ARFI) elastography in the diagnosis of liver fibrosis in chronic hepatitis B and C patients through Meta-analysis. MATERIAL AND METHODS: Four databases (PubMed, the Cochrane Library, WanFang data, and CNKI) were searched. The key words were: ("ARFI" or "acoustic radiation force impulse") combined with " liver fibrosis" and (" chronic hepatitis" or "HBV HCV"). Heterogeneity (I2) was assessed, and its source was analyzed through meta-regression. RESULTS: 21 articles with 2,691 patients were included. The compositeSe=0.79 (95% CI: 0.76-0.83) and Sp=0.86 (95% CI: 0.85-0.88). ARFI elastography showed a better ability to evaluate higherstage liver fibrosis and liver cirrhosis (F=3 and F=4, respectively). For F≥3, Se=0.84 (95% CI: 0.80-0.88, I2=61.37), Sp=0.90 (95% CI: 0.86-0.92, I2=65.10), and AUROC=0.94 (95% CI: 0.91-0.95). Se and Sp and AUROC of F=4 were 0.86 (95% CI: 0.80-0.91, I2=70.67), 0.84 (95% CI: 0.80-0.88, I2=78.94) and 0.91 (95% CI: 0.89-0.94), respectively. Besides, the combined RFI values indicate that CHC patients had higher ARFI values especially in the F3 stage (1.87 [95% CI: 1.67-2.06] and 2.31[95% CI: 2.09-2.52] for CHB and CHC, respectively). CONCLUSION: ARFI elastography is accurate and reliable in the diagnosis of CHB- and CHC-induced liver fibrosis and is especially suitable for the evaluation of stages F≥3 and F=4. CHC patients manifest higher ARFI values than CHB patients especially in the F3 stage.
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Authors | Xiangdong Hu, Lanyan Qiu, Dong Liu, Linxue Qian |
Journal | Medical ultrasonography
(Med Ultrason)
Vol. 19
Issue 1
Pg. 23-31
(Jan 31 2017)
ISSN: 2066-8643 [Electronic] Romania |
PMID | 28180193
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Elasticity Imaging Techniques
(methods)
- Female
- Hepatitis B, Chronic
(complications)
- Hepatitis C, Chronic
(complications)
- Humans
- Liver
(diagnostic imaging, pathology)
- Liver Cirrhosis
(complications, diagnostic imaging)
- Male
- Middle Aged
- ROC Curve
- Reproducibility of Results
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