Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses.

Abstract	The interaction between the meiotic recombination 11 homolog A (MRE11) oncoprotein and breast cancer recurrence status remains unclear. The aim of this study was to assess the interaction between MRE11 and clinicopathologic variables in breast cancer. A dataset for 254 subjects with breast cancer (220 nonrecurrent and 34 recurrent) was used in individual and cumulated receiver operating characteristic (ROC) analyses of MRE11 and 12 clinicopathologic variables for predicting breast cancer recurrence. In individual ROC analysis, the area under curve (AUC) for each predictor of breast cancer recurrence was smaller than 0.7. In cumulated ROC analysis, however, the AUC value for each predictor improved. Ten relevant variables in breast cancer recurrence were used to find the optimal prognostic indicators. The presence of any six of the following ten variables had a high (79%) sensitivity and a high (70%) specificity for predicting breast cancer recurrence: tumor size ≥ 2.4 cm, tumor stage II/III, therapy other than hormone therapy, age ≥ 52 years, MRE11 positive cells > 50%, body mass index ≥ 24, lymph node metastasis, positivity for progesterone receptor, positivity for epidermal growth factor receptor, and negativity for estrogen receptor. In conclusion, this study revealed that these 10 clinicopathologic variables are the minimum discriminators needed for optimal discriminant effectiveness in predicting breast cancer recurrence.
Authors	Cheng-Hong Yang, Sin-Hua Moi, Li-Yeh Chuang, Shyng-Shiou F Yuan, Ming-Feng Hou, Yi-Chen Lee, Hsueh-Wei Chang
Journal	BioMed research international (Biomed Res Int) Vol. 2017 Pg. 2563910 ( 2017) ISSN: 2314-6141 [Electronic] United States
PMID	28133604 (Publication Type: Journal Article)
Chemical References	DNA-Binding Proteins MRE11 protein, human MRE11 Homologue Protein
Topics	Area Under Curve Breast Neoplasms (metabolism, pathology) DNA-Binding Proteins (metabolism) Female Humans MRE11 Homologue Protein Middle Aged Neoplasm Recurrence, Local (metabolism, pathology) ROC Curve Risk Factors

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