Association between 24-hour combined multichannel intraluminal impedance-pH monitoring and symptoms or quality of life in patients with laryngopharyngeal reflux.

Abstract

OBJECTIVE:

To evaluate the association between the parameters of 24-hour multichannel intraluminal impedance (MII)-pH monitoring and the symptoms or quality of life (QoL) in laryngopharyngeal reflux (LPR) patients.

DESIGN:

Prospective cohort study without controls.

SETTING:

University teaching hospital.

METHODS:

Forty-five LPR patients were selected from subjects who underwent 24-hour MII-pH monitoring and were diagnosed with LPR from September 2014 to May 2015. Reflux Symptom Index (RSI), Health-related Quality of Life (HRQoL), Short Form 12 (SF-12) Survey questionnaires were surveyed. Spearman's correlation was used to analyse the association between the symptoms or QoL and 24-hour MII-pH monitoring.

RESULTS:

Most parameters in 24-hour MII-pH monitoring showed weak or no correlation with RSI, HRQoL and SF-12. Only number of non-acid reflux events that reached the larynx and pharynx (LPR-non-acid) and number of total reflux events that reached the larynx and pharynx (LPR-total) parameters showed strong correlation with heartburn in RSI (R = 0.520, P < 0.001, R = 0.478, P = 0.001, respectively). Multiple regression analysis showed that there was only one significant regression coefficient between LPR-non-acid and voice/hoarseness portion of HRQoL (b = 1.719, P = 0.022).

CONCLUSION:

Most parameters of 24-hour MII-pH monitoring did not reflect subjective symptoms or QoL in patients with LPR.

• Authors: S I Kim, O E Kwon, S Y Na, Y C Lee, J M Park, Y G Eun
• Journal: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (Clin Otolaryngol) Vol. 42 Issue 3 Pg. 584-591 (Jun 2017) ISSN: 1749-4486 [Electronic] England
• PMID: 28004504 (Publication Type: Journal Article)
• Copyright: © 2017 John Wiley & Sons Ltd.

Topics

• Electric Impedance
• Esophageal pH Monitoring (methods)
• Esophagus (metabolism, physiopathology)
• Female
• Follow-Up Studies
• Humans
• Laryngopharyngeal Reflux (diagnosis, physiopathology, psychology)
• Larynx (metabolism, physiopathology)
• Male
• Middle Aged
• Prognosis
• Prospective Studies
• Quality of Life
• Severity of Illness Index
• Surveys and Questionnaires