Crosslinking of poly(vinylpyrrolidone)/acrylic acid with tragacanth gum for hydrogels formation for use in drug delivery applications.

Abstract

Tragacanth gum (TG) is generally recognized as safe by the Food and Drug Administration. The present article discusses the design of ciprofloxacin loaded TG based hydrogels for use in drug delivery especially to improve the pharmacotherapy of diverticulitis. The polymers were characterized by SEMs, FTIR, 13C NMR, XRD, TGA, DSC, gel strength and swelling studies. The polymer network parameters, mucoadhesion, gel strength, drug release mechanism and kinetic model were also determined. The release of drug occurred through non-Fickian diffusion mechanism and best fitted in the Korsmeyer-Peppas model. The pH of the swelling medium has also exerted a strong effect on polymer network structure and mechanical strength. These hydrogels have been observed pH responsive and mucoadhesive in nature and could be utilized for site specific drug delivery.

• Authors: Baljit Singh, Vikrant Sharma
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 157 Pg. 185-195 (Feb 10 2017) ISSN: 1879-1344 [Electronic] England
• PMID: 27987904 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Ltd. All rights reserved.

Chemical References

• Acrylates
• Drug Carriers
• Hydrogels
• Plant Gums
• Tragacanth
• Povidone
• acrylic acid

Topics

• Acrylates (chemistry)
• Avena
• Drug Carriers (chemistry)
• Drug Liberation
• Hemolysis
• Humans
• Hydrogels (chemistry)
• Hydrogen-Ion Concentration
• Plant Gums (chemistry)
• Povidone (chemistry)
• Tragacanth (chemistry)