Sequel of MgO nanoparticles in PLACL nanofibers for anti-cancer therapy in synergy with curcumin/β-cyclodextrin.

Abstract

Pharmaceutical industries spend more money in developing new and efficient methods for delivering successful drugs for anticancer therapy. Electrospun nanofibers and nanoparticles loaded with drugs have versatile biomedical applications ranging from wound healing to anticancer therapy. We aimed to attempt for fabricating elastomeric poly (l-lactic acid-co-ε-caprolactone) (PLACL) with Aloe Vera (AV), magnesium oxide (MgO) nanoparticles, curcumin (CUR) and β-cyclodextrin (β-CD) composite nanofibers to control the growth of MCF-7 cells for breast cancer therapy. The study focused on the interaction of MgO nanoparticle with CUR and β-CD inhibiting the proliferation of Michigan Cancer Foundation-7 (MCF-7) breast cancer cells. FESEM micrographs of fabricated electrospun PLACL, PLACL/AV, PLACL/AV/MgO, PLACL/AV/MgO/CUR and PLACL/AV/MgO/β-CD nanofibrous scaffolds achieved bead free, random and uniform nanofibers with fiber diameter in the range of 786±286, 507±171, 334±95, 360±94 and 326±80nm respectively. Proliferation of MCF-7 cells was decreased by 65.92% in PLACL/AV/MgO/CUR with respect to PLACL/AV/MgO nanofibrous scaffolds on day 9. The obtained results proved that 1% CUR interacting with MgO nanoparticles showed higher inhibition of MCF-7 cells among all other nanofibrous scaffolds thus serving as a promising biocomposite material system for the breast cancer therapy.

• Authors: Shruthi Vathaluru Sudakaran, Jayarama Reddy Venugopal, Gnaneshwar Puvala Vijayakumar, Sivasubramanian Abisegapriyan, Andrews Nirmala Grace, Seeram Ramakrishna
• Journal: Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 71 Pg. 620-628 (Feb 01 2017) ISSN: 1873-0191 [Electronic] Netherlands
• PMID: 27987753 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Manganese Compounds
• Oxides
• Polyesters
• beta-Cyclodextrins
• poly(lactic acid-co-epsilon-caprolactone)
• manganese oxide
• Curcumin

Topics

• Antineoplastic Agents, Phytogenic (chemistry, pharmacokinetics, pharmacology)
• Breast Neoplasms (drug therapy, metabolism, pathology)
• Cell Proliferation (drug effects)
• Curcumin (chemistry, pharmacokinetics, pharmacology)
• Female
• Humans
• MCF-7 Cells
• Manganese Compounds (chemistry, pharmacokinetics, pharmacology)
• Nanofibers (chemistry)
• Nanoparticles (chemistry)
• Oxides (chemistry, pharmacokinetics, pharmacology)
• Polyesters (chemistry, pharmacokinetics, pharmacology)
• beta-Cyclodextrins (chemistry, pharmacokinetics, pharmacology)