Abstract | BACKGROUND: Previous large population studies reported that non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease than TG in the fasting plasma. This is suggestive of the presence of higher concentration of remnant lipoproteins (RLP) in postprandial plasma. METHODS: RESULTS: RLP-TG/TG ratio (concentration) and RLP-TG/RLP-C ratio (particle size) were significantly increased in the postprandial plasma of both healthy controls and CAD patients compared with those in fasting plasma. LPL/RLP-TG ratio demonstrated the interaction correlation between RLP concentration and LPL activity The increased RLP-TG after fat consumption contributed to approximately 90% of the increased plasma TG, while approximately 60% after a typical meal. Plasma LPL in postprandial plasma was not significantly altered after either type of meal. CONCLUSIONS: Concentrations of RLP-TG found in the TG along with its particle size are significantly increased in postprandial plasma compared with fasting plasma. Therefore, non-fasting TG determination better reflects the presence of higher RLP concentrations in plasma.
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Authors | Katsuyuki Nakajima, Yoshiharu Tokita, Koji Sakamaki, Younosuke Shimomura, Junji Kobayashi, Keiko Kamachi, Akira Tanaka, Kimber L Stanhope, Peter J Havel, Tao Wang, Tetsuo Machida, Masami Murakami |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 465
Pg. 45-52
(Feb 2017)
ISSN: 1873-3492 [Electronic] Netherlands |
PMID | 27986550
(Publication Type: Journal Article, Multicenter Study)
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Copyright | Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Lipoproteins
- Triglycerides
- LPL protein, human
- Lipoprotein Lipase
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Topics |
- Adult
- Aged
- Cardiovascular Diseases
(blood)
- Case-Control Studies
- Eating
(physiology)
- Fasting
(blood)
- Female
- Humans
- Lipoprotein Lipase
(blood)
- Lipoproteins
(blood)
- Male
- Middle Aged
- Particle Size
- Risk Factors
- Triglycerides
(blood)
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