Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features.

Abstract

The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 18:3, ω-3) and gamma-linolenic acid (GLA, 18:3, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect.

• Authors: Sneha Yadav, Virendra Tiwari, Manjari Singh, Rajnish K Yadav, Subhadeep Roy, Uma Devi, Swetlana Gautam, Jitendra Kumar Rawat, Mohd Nazam Ansari, Abdulaziz Sa Saeedan, Anand Prakash, Shubhini A Saraf, Gaurav Kaithwas
• Journal: Journal of physiology and biochemistry (J Physiol Biochem) Vol. 73 Issue 2 Pg. 187-198 (May 2017) ISSN: 1877-8755 [Electronic] Spain
• PMID: 27878518 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Anticonvulsants
• Antimanic Agents
• Biomarkers
• Inflammation Mediators
• Nerve Tissue Proteins
• Neuroprotective Agents
• alpha-Linolenic Acid
• Valproic Acid
• gamma-Linolenic Acid
• UCHL1 protein, rat
• Ubiquitin Thiolesterase

Topics

• Animals
• Animals, Newborn
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use)
• Anticonvulsants (toxicity)
• Antimanic Agents (toxicity)
• Autistic Disorder (chemically induced, immunology, pathology, prevention & control)
• Behavior, Animal (drug effects)
• Biomarkers (blood, metabolism)
• Brain (drug effects, immunology, metabolism, pathology)
• Dietary Supplements (adverse effects)
• Disease Models, Animal
• Inflammation Mediators (blood, metabolism)
• Nerve Tissue Proteins (metabolism)
• Neurons (drug effects, immunology, metabolism, pathology)
• Neuroprotective Agents (adverse effects, therapeutic use)
• Oxidative Stress (drug effects)
• Rats, Wistar
• Ubiquitin Thiolesterase (metabolism)
• Valproic Acid (toxicity)
• alpha-Linolenic Acid (adverse effects, blood, metabolism, therapeutic use)
• gamma-Linolenic Acid (adverse effects, blood, metabolism, therapeutic use)