[Systematic review with meta-analysis: Subcutaneous insulin glargine coadministration for diabetic ketoacidosis].

Abstract

BACKGROUND:

The standard treatment of diabetic ketoacidosis involves intravenous infusion of regular insulin until recovery of the episode: this is associated with high costs. Coadministration of insulin glargine from the onset of management may prove beneficial, potentially avoiding rebound hyperglycemia, and hopefully improving the time to resolution of the disease.

METHODS:

We searched MEDLINE, EMBASE, and CENTRAL for randomized controlled trials comparing coadministration of insulin glargine versus standard treatment in patients with diabetic ketoacidosis. To be eligible, studies must assess the efficacy of insulin glargine and report clinically important outcomes. Two reviewers extracted data, assessed risk of bias and summarized strength of evidence using the GRADE approach.

RESULTS:

Four studies (135 participants during hospital follow-up) were included in this review. Low-quality evidence from three trials suggested that subcutaneously administered insulin glargine, in addition to the standard treatment, significantly reduces the time to resolution of diabetic ketoacidosis (MD -4.19 hours; 95% CI: -7.81 to 0.57; p = 0.02). There was neutral difference between the two groups regarding length of hospital stay and hypoglycemic episodes.

CONCLUSIONS:

subcutaneously administered insulin glargine, in addition to standard treatment, significantly reduces the time to resolution of diabetic ketoacidosis, with neutral effects on hypoglycemic episodes.

• Authors: Carlos Alberto Andrade-Castellanos, Luis Enrique Colunga-Lozano
• Journal: Gaceta medica de Mexico (Gac Med Mex) 2016 Nov - Dec Vol. 152 Issue 6 Pg. 761-769 ISSN: 0016-3813 [Print] Mexico
• Vernacular Title: Revisión sistemática con metaanálisis. Coadministración de insulina glargina en el manejo de la cetoacidosis diabética (CAD).
• PMID: 27861474 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)

Chemical References

• Hypoglycemic Agents
• Insulin Glargine

Topics

• Diabetic Ketoacidosis (drug therapy)
• Humans
• Hyperglycemia (prevention & control)
• Hypoglycemia
• Hypoglycemic Agents (administration & dosage)
• Injections, Subcutaneous
• Insulin Glargine (administration & dosage)