[Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD): Somatostatin analogues and mTOR inhibitors].

Abstract

Recent advances in the understanding of the molecular mechanisms underlying autosomal dominant polycystic kidney disease (ADPKD) set the stage for the development of various treatments aimed to arrest or delay disease progression. In particular, clinical trials showed that the use of somatostatin analogues in patients with ADPKD is able to slow down the increase in total kidney volume and the progressive decline in renal function over the long-term. Treatment with these agents is generally well tolerated and it also enables to control cyst growth in the liver in patients with this extra-renal manifestation of the disease. By contrast, mammalian target of rapamycin (mTOR) inhibitors, although promising in different experimental models of kidney and liver disease, in most clinical studies they were not effective in slowing cystic kidney growth and/or improving the progressive renal function decline in patients with ADPKD. Therapy with mTOR inhibitors is also limited by the elevated incidence of adverse events, which frequently requires drug withdrawal or dose reduction, eventually nullifying the potential renoprotective effect.

• Authors: Norberto Perico, Monica Cortinovis, Giuseppe Remuzzi
• Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia (G Ital Nefrol) 2016 Sep-Oct Vol. 33 Issue 5 ISSN: 1724-5990 [Electronic] Italy
• Vernacular Title: Trattamento della malattia policistica autosomica dominanate del rene (ADPKD): analoghi della somatostatina e inibitori mTOR.
• PMID: 27796020 (Publication Type: Journal Article)

Chemical References

• Somatostatin
• MTOR protein, human
• TOR Serine-Threonine Kinases

Topics

• Humans
• Polycystic Kidney, Autosomal Dominant (drug therapy)
• Practice Guidelines as Topic
• Somatostatin (analogs & derivatives)
• TOR Serine-Threonine Kinases (antagonists & inhibitors)