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Providing Evidence for Subclinical CVD in Risk Assessment.

Abstract
When the MESA (Multi-Ethnic Study of Atherosclerosis) began, the Framingham risk score was the preferred tool for 10-year global coronary heart disease risk assessment; however, the Framingham risk score had limitations including derivation in a homogenous population lacking racial and ethnic diversity and exclusive reliance on traditional risk factors without consideration of most subclinical disease measures. MESA was designed to study the prognostic value of subclinical atherosclerosis and other risk markers in a multiethnic population. In a series of landmark publications, MESA demonstrated that measures of subclinical cardiovascular disease add significant prognostic value to the traditional Framingham risk variables. In head-to-head studies comparing these markers, MESA established that the coronary artery calcium score may be the single best predictor of coronary heart disease risk. Results from MESA have directly influenced recent prevention guidelines including the recommendations on risk assessment and cholesterol-lowering therapy. The MESA study has published its own risk score, which allows for the calculation of 10-year risk of coronary heart disease before and after knowledge of a coronary artery calcium score.
AuthorsMichael J Blaha, Joseph Yeboah, Mahmoud Al Rifai, Kiang Liu, Richard Kronmal, Philip Greenland
JournalGlobal heart (Glob Heart) Vol. 11 Issue 3 Pg. 275-285 (09 2016) ISSN: 2211-8179 [Electronic] England
PMID27741975 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2016 World Heart Federation (Geneva). Published by Elsevier B.V. All rights reserved.
Chemical References
  • Biomarkers
Topics
  • Aged
  • Ankle Brachial Index
  • Biomarkers (metabolism)
  • Carotid Intima-Media Thickness
  • Coronary Artery Disease (complications)
  • Coronary Disease (diagnostic imaging, etiology)
  • Disease Progression
  • Female
  • Forecasting
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Physician-Patient Relations
  • Plaque, Atherosclerotic (complications, diagnostic imaging)
  • Practice Guidelines as Topic
  • ROC Curve
  • Risk Assessment (methods)
  • Vascular Calcification (complications, diagnostic imaging)

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