Abstract | BACKGROUND: Outcome of patients with streptococcal prosthetic joint infections (PJIs) is not well known. METHODS: We performed a retrospective multicenter cohort study that involved patients with total hip/knee prosthetic joint (THP/ TKP) infections due to Streptococcus spp. from 2001 through 2009. RESULTS: Ninety-five streptococcal PJI episodes (50 THP and 45 TKP) in 87 patients of mean age 69.1 ± 13.7 years met the inclusion criteria. In all, 55 out of 95 cases (57.9 %) were treated with debridement and retention of the infected implants with antibiotic therapy (DAIR). Rifampicin-combinations, including with levofloxacin, were used in 52 (54.7 %) and 28 (29.5 %) cases, respectively. After a mean follow-up period of 895 days (IQR: 395-1649), the remission rate was 70.5 % (67/95). Patients with PJIs due to S. agalactiae failed in the same proportion as in the other patients (10/37 (27.1 %) versus 19/58 (32.7 %); p = .55). In the univariate analysis, antibiotic monotherapy, DAIR, antibiotic treatments other than rifampicin-combinations, and TKP were all associated with a worse outcome. The only independent variable significantly associated with the patients' outcomes was the location of the prosthesis (i.e., hip versus knee) (OR = 0.19; 95 % CI 0.04-0.93; p value 0.04). CONCLUSIONS:
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Authors | E Fiaux, M Titecat, O Robineau, J Lora-Tamayo, Y El Samad, M Etienne, N Frebourg, N Blondiaux, B Brunschweiler, F Dujardin, E Beltrand, C Loiez, V Cattoir, J P Canarelli, C Hulet, M Valette, S Nguyen, F Caron, H Migaud, E Senneville, G4 bone and joint infection study group (G4BJIS) |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 16
Issue 1
Pg. 568
(10 13 2016)
ISSN: 1471-2334 [Electronic] England |
PMID | 27737642
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Anti-Bacterial Agents
- Levofloxacin
- Rifampin
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Topics |
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(administration & dosage)
- Arthritis
(drug therapy)
- Arthroplasty, Replacement, Knee
(adverse effects)
- Drug Therapy, Combination
- Female
- Hip Prosthesis
(adverse effects, microbiology)
- Humans
- Knee Joint
(microbiology, surgery)
- Knee Prosthesis
(adverse effects, microbiology)
- Levofloxacin
(administration & dosage)
- Male
- Middle Aged
- Prosthesis-Related Infections
(diagnosis, drug therapy)
- Retrospective Studies
- Rifampin
(administration & dosage)
- Streptococcal Infections
(drug therapy, etiology)
- Treatment Outcome
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