In vitro activity of tedizolid against Staphylococcus aureus and Streptococcus pneumoniae collected in 2013 and 2014 from sites in Latin American countries, Australia, New Zealand, and China.

Abstract

Tedizolid is an oxazolidinone with an antimicrobial in vitro potency advantage against Gram-positive bacterial pathogens compared to other currently marketed drugs in this class, including linezolid. Tedizolid was compared to linezolid when tested against Staphylococcus aureus and Streptococcus pneumoniae isolates collected from countries in Latin America and the Asia-Pacific. Isolates were tested by broth microdilution susceptibility methods against tedizolid, linezolid, and non-class comparators in accordance with the Clinical and Laboratory Standards Institute (CLSI) guidelines. The activity of tedizolid against S. aureus was potent and consistent in Latin America (MIC90, 0.5 mg/L), Australia and New Zealand (MIC90, 0.25 mg/L), and China (MIC90, 0.5 mg/L). Based on MIC90 results, tedizolid was four- to eight-fold more active than linezolid against S. aureus, including both methicillin-susceptible and -resistant isolates. Only two tedizolid non-susceptible strains were observed; both had intermediate minimum inhibitory concentration (MIC) values of 1 mg/L, for which the MICs of linezolid was higher (≥2 mg/L). Tedizolid (MIC90, 0.25 mg/L) was four-fold more potent than linezolid (MIC90, 1 mg/L) against S. pneumoniae in all countries that provided isolates. The findings from this study support the global clinical development of tedizolid for Gram-positive infections.

• Authors: D J Biedenbach, S K Bouchillon, B Johnson, J Alder, D F Sahm
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 35 Issue 12 Pg. 1933-1939 (Dec 2016) ISSN: 1435-4373 [Electronic] Germany
• PMID: 27677280 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Organophosphates
• Oxazoles
• Linezolid
• tedizolid phosphate

Topics

• Anti-Bacterial Agents (pharmacology)
• Australasia
• China
• Humans
• Latin America
• Linezolid (pharmacology)
• Microbial Sensitivity Tests
• Organophosphates (pharmacology)
• Oxazoles (pharmacology)
• Staphylococcus aureus (drug effects, isolation & purification)
• Streptococcus pneumoniae (drug effects, isolation & purification)