Roles of LPA receptor signaling in breast cancer.

Abstract

INTRODUCTION:

LPA and its receptors play an important role in mediating malignant behaviors in various cancers, including breast cancer. Aberrant expression of certain LPA receptors in breast cancer suggested that LPA receptors could be potential biomarkers in understanding malignant growth patterns of breast cancer. Further research considering molecular mechanisms for LPA receptors will contribute to new methods of malignant breast cancer diagnosis and treatment. Areas covered: Accumulating studies have indicated that LPA receptors correlated to proliferation, invasion, migration and metastasis both in vivo and in vitro. In this manuscript, we have reviewed LPA receptors expressions and LPA mediated biological behaviors in cell lines, mouse models and patients and their potential molecular pathways. Expert commentary: LPA receptors could be applied in early diagnosis, survival rate prediction, metastasis probability and potential treatment targets. However, further studies are required to clarify the upstream and downstream molecular mechanisms of LPA receptors in breast cancer.

• Authors: Jizhao Wang, Yuchen Sun, Jingkun Qu, Yan Yan, Ya Yang, Hui Cai
• Journal: Expert review of molecular diagnostics (Expert Rev Mol Diagn) Vol. 16 Issue 10 Pg. 1103-1111 (10 2016) ISSN: 1744-8352 [Electronic] England
• PMID: 27644846 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Biomarkers
• Lysophospholipids
• Receptors, Lysophosphatidic Acid
• Phosphoric Diester Hydrolases
• alkylglycerophosphoethanolamine phosphodiesterase

Topics

• Animals
• Antineoplastic Agents (pharmacology, therapeutic use)
• Biomarkers
• Breast Neoplasms (drug therapy, genetics, metabolism, pathology)
• Cell Movement
• Cell Proliferation
• Cell Transformation, Neoplastic (genetics, metabolism)
• Disease Progression
• Drug Resistance, Neoplasm
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Lysophospholipids (biosynthesis)
• Phosphoric Diester Hydrolases (metabolism)
• Receptors, Lysophosphatidic Acid (antagonists & inhibitors, genetics, metabolism)
• Signal Transduction
• Transcriptome