Abstract | BACKGROUND: METHODS: This was a retrospective analysis of all consecutive patients who underwent liver resection for intrahepatic cholangiocarcinoma with curative intent in 24 university hospitals between 1989 and 2009. Severe morbidity was defined as any complication of Dindo-Clavien grade III or IV. Patients with severe morbidity were compared with those without in terms of demographics, pathology, management, morbidity, overall survival, disease-free survival and time to recurrence. Independent predictors of severe morbidity were identified by multivariable analysis. RESULTS: A total of 522 patients were enrolled. Severe morbidity occurred in 113 patients (21·6 per cent) and was an independent predictor of overall survival (hazard ratio 1·64, 95 per cent c.i. 1·21 to 2·23), as were age at resection, multifocal disease, positive lymph node status and R0 resection margin. Severe morbidity did not emerge as an independent predictor of disease-free survival. Independent predictors of time to recurrence included severe morbidity, tumour size, multifocal disease, vascular invasion and R0 resection margin. Major hepatectomy and intraoperative transfusion were independent predictors of severe morbidity. CONCLUSION:
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Authors | A Doussot, C Lim, C Gómez-Gavara, D Fuks, O Farges, J M Regimbeau, D Azoulay, AFC-IHCC Study Group |
Journal | The British journal of surgery
(Br J Surg)
Vol. 103
Issue 13
Pg. 1887-1894
(12 2016)
ISSN: 1365-2168 [Electronic] England |
PMID | 27629502
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © 2016 BJS Society Ltd Published by John Wiley & Sons Ltd. |
Topics |
- Bile Duct Neoplasms
(mortality, surgery)
- Cholangiocarcinoma
(mortality, surgery)
- Disease-Free Survival
- Female
- Hepatectomy
(methods, mortality)
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(mortality)
- Postoperative Complications
(etiology, mortality)
- Retrospective Studies
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