Autologous adrenal medullary transplant in progressive supranuclear palsy.

Abstract

We transplanted autologous adrenal medullary cells to the caudate nucleus in 3 patients with progressive supranuclear palsy, using the method Madrazo has employed for neural transplantation in Parkinson's disease. Major and minor complications occurred post-operatively from which the patients recovered. One patient had a marked improvement in his postural stability and a decreased incidence of falling. This change was evident at 1 month after surgery and has remained for the 6 months of follow-up. Postural reflexes were not altered in the other 2 patients. There was no change in extraocular movements, speech, or the rigid-bradykinetic features of parkinsonism in any patient. Adrenal medullary transplantation has only limited efficacy in progressive supranuclear palsy.

• Authors: W C Koller, R Morantz, B Vetere-Overfield, M Waxman
• Journal: Neurology (Neurology) Vol. 39 Issue 8 Pg. 1066-8 (Aug 1989) ISSN: 0028-3878 [Print] United States
• PMID: 2761701 (Publication Type: Journal Article)

Topics

• Adrenal Medulla (transplantation)
• Aged
• Evaluation Studies as Topic
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Postoperative Complications
• Posture
• Reflex
• Supranuclear Palsy, Progressive (physiopathology, surgery)
• Time Factors