Abstract | BACKGROUND AND AIM: METHODS: We evaluated the records of 2323 consecutive eligible patients who underwent both a total colonoscopy (TCS) and PET between October 2002 and September 2012 at a tertiary cancer center. The PET findings were verified by TCS performed independently within 1 year. Target lesions were defined as CRCs and adenomas that were 6 mm or larger in size. RESULTS: Total colonoscopy detected 532 target lesions ≥ 6 mm in size: 56 T2-T4 CRCs, 39 T1 CRCs, 223 advanced adenomas, and 214 low-grade adenomas. Of the 532 lesions, 216 (40.6%) were PET positive. Of the 369 cases with positive uptakes, PET detected target lesions in the matched segments for 58.5% (216/369). Sensitivity of PET to T2-T4 CRCs, T1 CRCs, advanced adenomas, and low-grade adenomas was 92.9%, 79.5%, 50.7%, and 9.3%, respectively. PET could detect 76.5% (13/17) of T1 CRCs whose size is 10 to 19 mm and 85.0% (17/20) of T1 CRCs equal or larger than 20 mm. The multivariate analysis excluding T2-T4 CRCs showed malignant histology, larger size, protruded lesions, villous histology, and lesions in distal colon were significant factors. CONCLUSIONS: Sensitivity of PET for detecting T2-T4 and even T1 cancers are promising. However, sensitivity of PET to adenomas, even advanced adenomas, is limited.
|
Authors | Kimihiro Igarashi, Kinichi Hotta, Kenichiro Imai, Yuichiro Yamaguchi, Sayo Ito, Noboru Kawata, Masaki Tanaka, Naomi Kakushima, Kohei Takizawa, Hiroyuki Matsubayashi, Masahiro Endo, Kouiku Asakura, Takuma Oishi, Tadakazu Shimoda, Hiroyuki Ono |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 32
Issue 3
Pg. 602-608
(Mar 2017)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 27548332
(Publication Type: Journal Article)
|
Copyright | © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Fluorine Radioisotopes
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
|
Topics |
- Adenoma
(diagnostic imaging, pathology)
- Adult
- Aged
- Aged, 80 and over
- Colonoscopy
- Colorectal Neoplasms
(diagnostic imaging, pathology)
- Female
- Fluorine Radioisotopes
- Fluorodeoxyglucose F18
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Positron-Emission Tomography
- Radiopharmaceuticals
- Sensitivity and Specificity
- Young Adult
|