SYSTEMIC HISTIOCYTIC SARCOMA IN A COMMON HIPPOPOTAMUS (HIPPOPOTAMUS AMPHIBIUS).

Abstract

A 37-yr-old captive common hippopotamus (Hippopotamus amphibius) developed lethargy and decline in mobility that progressed to death, despite supportive therapy. Histopathologic examination revealed severe, diffuse, intravascular and interstitial infiltration of neoplastic histiocytes in the spleen, liver, lymph nodes, lungs, large intestine, kidneys, and thyroid gland. Neoplastic cells were pleomorphic with marked anisocytosis and anisokaryosis, scattered multinucleated giant cells, numerous bizarre mitotic figures, and marked erythrophagocytosis. Immunohistochemistry demonstrated that neoplastic cells were positive for ionized calcium-binding adapter molecule 1 (a histiocytic marker) and negative for CD3 (a T-cell marker) and myeloperoxidase, confirming the diagnosis of systemic histiocytic sarcoma.

• Authors: Luciana Fachini da Costa, Marcelo Campos Cordeiro Malta, Herlandes Penha Tinoco, Lilian Botelho de Medeiros, Ana Luiza Sarkis Vieira Bittar, Aline Rodrigues Hoffmann, Felipe Pierezan, Tatiane Alves da Paixão, Renato Lima Santos
• Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians (J Zoo Wildl Med) Vol. 47 Issue 2 Pg. 650-3 (Jun 2016) ISSN: 1042-7260 [Print] United States
• PMID: 27468044 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Artiodactyla
• Fatal Outcome
• Female
• Histiocytic Sarcoma (pathology, veterinary)