Anti-ganglioside antibodies in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy in Chinese patients.

Abstract

INTRODUCTION:

In this study we investigated the relationships between anti-ganglioside antibodies and Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP).

METHODS:

Samples from 48 Chinese patients diagnosed with GBS and 18 patients diagnosed with CIDP were retrospectively reviewed.

RESULTS:

In the GBS patients, 62.5% were classified as having acute inflammatory demyelinating polyneuropathy (AIDP), 27.1% were found to have acute motor axonal neuropathy (AMAN), and 10.4% were unclassified. Serum IgG anti-ganglioside antibodies were detected in 46.2% of the AMAN patients and in 6.7% of the AIDP patients (P < 0.05); 5.6% of the 18 CIDP patients were IgG antibody positive, and 27.8% were IgM antibody positive. Facial palsy and sensory impairment were significantly associated with IgM antibodies.

CONCLUSIONS:

These results suggest that IgG anti-GM1 antibodies are associated with AMAN, but not with AIDP, and that IgM antibodies against GM1, GM2, and GM3 are associated with facial nerve palsy. Muscle Nerve 55: 470-475, 2017.

• Authors: Chenghe Fan, Haiqiang Jin, Hongjun Hao, Feng Gao, Yongan Sun, Yuanyuan Lu, Yuanyuan Liu, Pu Lv, Wei Cui, Yuming Teng, Yining Huang
• Journal: Muscle & nerve (Muscle Nerve) Vol. 55 Issue 4 Pg. 470-475 (04 2017) ISSN: 1097-4598 [Electronic] United States
• PMID: 27464289 (Publication Type: Journal Article)
• Copyright: © 2016 Wiley Periodicals, Inc.

Chemical References

• Autoantibodies
• Gangliosides

Topics

• Action Potentials (physiology)
• Adult
• Aged
• Aged, 80 and over
• Asian People
• Autoantibodies (blood, cerebrospinal fluid)
• Electromyography
• Female
• Gangliosides (immunology)
• Guillain-Barre Syndrome (blood, cerebrospinal fluid, immunology)
• Humans
• Male
• Middle Aged
• Neural Conduction (physiology)
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (blood, cerebrospinal fluid, immunology)