Dietary intakes of citrus fruit and risk of gastric cancer incidence: an adaptive meta-analysis of cohort studies.

Abstract

OBJECTIVES:

In the context of supplementary antioxidants having no anticancer effect, it is important to update the meta-analysis to evaluate whether there is an association between intake of citrus fruit and gastric cancer risk.

METHODS:

The list of articles to be searched was established using citation discovery tools provided by PubMed and Scopus. The effect size of each article to be used in meta-analysis was calculated using the interval-collapse method. Summary effect size (sES) and 95% confidence intervals (CI) were obtained by conducting this meta-analysis. Random effect dose-response meta-regression (DRMR) was performed to investigate the dose-response relationship.

RESULTS:

A total of five cohort studies were selected. The result was 13% reduction of gastric cancer according to the intake of citrus fruit (sES, 0.87; 95% CI, 0.76 to 0.99; I-squared=69.6%). In subgroup analysis, it was found that the intake of citrus fruit inhibited cardia gastric cancer (CGC) (sES, 0.67; 95% CI, 0.55 to 0.81; I-squared=46.1%) and as a result of DRMR, 100 g of citrus fruit intake per day inhibits CGC by 40% (relative risk, 0.60; 95% CI, 0.44 to 0.83).

CONCLUSIONS:

It is suggested that the intake of citrus fruit inhibits the development of CGC. This conclusion can be used as a primary prevention measure in the future when the incidence of CGC may be on the rise.

• Authors: Jong-Myon Bae, Eun Hee Kim
• Journal: Epidemiology and health (Epidemiol Health) Vol. 38 Pg. e2016034 ( 2016) ISSN: 2092-7193 [Electronic] Korea (South)
• PMID: 27457064 (Publication Type: Journal Article, Meta-Analysis, Review)

Topics

• Citrus
• Cohort Studies
• Diet (statistics & numerical data)
• Humans
• Incidence
• Risk Factors
• Stomach Neoplasms (epidemiology, prevention & control)