Abstract | INTRODUCTION: SOURCES OF DATA: Peer-reviewed journal articles and reviews. PubMed.gov AREAS OF AGREEMENT: The pathogenesis of ALS remains largely unknown. There are a wide range of potential mechanisms related to neurodegeneration. An increasing number of genetic factors are recognized. AREAS OF CONTROVERSY: There remains controversy, or lack of knowledge, in explaining how cellular events manifest as the complex human disease. There is controversy as to how well cellular and animal models of disease relate to the human disease. GROWING POINTS: Large-scale international collaborative genetic epidemiological studies are replacing local studies. Therapies related to pathogenesis remain elusive, with the greatest advances to date relating to provision of care (including multidisciplinary management) and supportive care (nutrition and respiratory support). AREAS TIMELY FOR DEVELOPING RESEARCH: The identification of C9orf72 hexanucleotide repeats as the most frequent genetic background to ALS, and the association with frontotemporal dementia, gives the potential of a genetic background against which to study other risk factors, triggers and pathogenic mechanisms, and to develop potential therapies.
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Authors | Sarah Morgan, Richard W Orrell |
Journal | British medical bulletin
(Br Med Bull)
Vol. 119
Issue 1
Pg. 87-98
(09 2016)
ISSN: 1471-8391 [Electronic] England |
PMID | 27450455
(Publication Type: Journal Article, Review)
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Copyright | © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected]. |
Chemical References |
- Anticonvulsants
- C9orf72 Protein
- C9orf72 protein, human
- DNA-Binding Proteins
- FUS protein, human
- Proteins
- RNA-Binding Protein FUS
- SOD1 protein, human
- TARDBP protein, human
- Riluzole
- Superoxide Dismutase-1
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Topics |
- Age of Onset
- Amyotrophic Lateral Sclerosis
(drug therapy, genetics, pathology, physiopathology)
- Anticonvulsants
(therapeutic use)
- C9orf72 Protein
- DNA-Binding Proteins
- Executive Function
(drug effects)
- Genome-Wide Association Study
- Humans
- Molecular Targeted Therapy
(trends)
- Mutation
(genetics)
- Proteins
- RNA-Binding Protein FUS
- Riluzole
(therapeutic use)
- Superoxide Dismutase-1
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