Feasibility and benefit of concurrent chemoradiotherapy for elderly patients with uterine cervical cancer.

Abstract

BACKGROUND:

Elderly patients with uterine cervical cancer reportedly have a poorer prognosis than younger patients. Until now, the benefit of concurrent chemoradiotherapy (CCRT) for elderly patients has been considered limited.

METHODS:

We retrospectively analyzed 49 women with cervical cancer aged >70 years primarily treated with radiotherapy (RT) or CCRT in our institute between 2003 and 2014. Treatment compliance, toxicity, and survival benefit were analyzed.

RESULTS:

A total of 49 patients were identified in this retrospective analysis. Twenty patients with a median age of 75.4 years (range 70-77) were treated with CCRT and 29 patients with a median age of 77.9 years (range 70-89) underwent RT. In the CCRT group, 14 patients (70%) completed CCRT consisting of radiotherapy and 5 courses of cisplatin plus 5-fluorouracil including patients requiring a dose reduction of chemotherapy. The median overall survival (OS) in the CCRT and RT groups was 66.9 and 60.1 months, respectively (p = 0.156). The most common grade 3/4 acute toxicity was hyponatremia (35.0%), followed by neutropenia (15.0%) and diarrhea (10.0%) in the CCRT group, while this was anemia (17.2%) followed by radiation enteritis (10.3%) in the RT group.

CONCLUSIONS:

CCRT was well tolerated in elderly patients with cervical cancer. Careful attention should be paid to the different characteristics of treatment-related toxicities in this group compared with younger patients.

• Authors: Kazuto Nosaka, Kiyosumi Shibata, Fumi Utsumi, Kosuke Yoshida, Kaoru Niimi, Ryuichiro Sekiya, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa
• Journal: Tumori (Tumori) Vol. 102 Issue 6 Pg. 600-605 (Dec 01 2016) ISSN: 2038-2529 [Electronic] United States
• PMID: 27443893 (Publication Type: Journal Article)

Topics

• Age Factors
• Aged
• Aged, 80 and over
• Chemoradiotherapy (adverse effects, methods)
• Comorbidity
• Female
• Humans
• Kaplan-Meier Estimate
• Neoplasm Staging
• Patient Compliance
• Retrospective Studies
• Treatment Outcome
• Uterine Cervical Neoplasms (diagnosis, mortality, therapy)