Partial prediction of postpartum Graves' thyrotoxicosis by sensitive bioassay for thyroid-stimulating antibody measured in early pregnancy.

Abstract

Graves' disease often occurs after delivery. However, it has been difficult to predict who will develop Graves' hyperthyroidism. We attempted to predict postpartum onset of Graves' disease by measuring anti-TSH receptor antibodies (TRAb) and thyroid-stimulating antibodies (TSAb) in early pregnancy. TRAb was measured by a third generation assay and TSAb was measured by a newly developed sensitive bioassay. In 690 early pregnant women, 2 showed borderline TRAb positive reactions. However, none of them developed Graves' disease after delivery. Thirty-eight of 690 pregnant women were positive for anti-thyroid peroxidase antibodies (TPOAb) and 4 were positive for TSAb. Two of these 4 women developed postpartum Graves' hyperthyroidism. These findings indicate that the third generation TRAb assay was not useful, but that the sensitive TSAb bioassay was moderately useful for predicting the postpartum onset of Graves' hyperthyroidism.

• Authors: Akane Ide, Nobuyuki Amino, Eijun Nishihara, Takumi Kudo, Mitsuru Ito, Yukiko Kimura, Nobuya Tatsumi, Mineo Yamazaki, Akira Miyauchi
• Journal: Endocrine journal (Endocr J) Vol. 63 Issue 10 Pg. 929-932 (Oct 29 2016) ISSN: 1348-4540 [Electronic] Japan
• PMID: 27432817 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Immunoglobulins, Thyroid-Stimulating
• thyroid microsomal antibodies
• thyrotropin-binding inhibitory immunoglobulin

Topics

• Autoantibodies (analysis, blood)
• Biological Assay (methods)
• Diagnostic Techniques, Endocrine
• Female
• Graves Disease (blood, diagnosis)
• Humans
• Immunoglobulins, Thyroid-Stimulating (analysis, blood)
• Postpartum Period (blood)
• Predictive Value of Tests
• Pregnancy
• Pregnancy Trimester, First (blood)
• Prenatal Diagnosis (methods)
• Prognosis
• Puerperal Disorders (blood, diagnosis)
• Sensitivity and Specificity
• Thyrotoxicosis (blood, diagnosis)