Outcomes after resection of occupational cholangiocarcinoma.

Abstract

BACKGROUND:

Cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane is recognized as occupational cholangiocarcinoma. The aim of this study was to investigate the outcomes after resection of occupational cholangiocarcinoma to establish a treatment strategy for this disease.

METHODS:

Clinicopathological findings and outcomes after surgical intervention in 20 patients with occupational cholangiocarcinoma were investigated.

RESULTS:

Of 20 the patients, curative resection was performed in 16 patients. Three patients underwent radiation at the stump of the bile ducts. Adjuvant chemotherapy was performed in 12 patients. Biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, and/or chronic bile duct injury was detected in most subjects. Intraabdominal infection developed after surgery in nine patients. Cholangiocarcinoma recurred in 12 of the 20 patients. The recurrent tumors in five patients developed at a different part of the bile duct from the primary tumor and a second resection was performed in four of these five patients.

CONCLUSIONS:

The incidence of postoperative complications including intraabdominal infection was high in patients with occupational cholangiocarcinoma. Multicentric recurrence occurred not infrequently after surgery because the bile ducts had a high potential for the development of carcinoma. The aggressive treatment including second resection for the multicentric recurrence appeared to be effective.

• Authors: Shoji Kubo, Shigekazu Takemura, Shogo Tanaka, Hiroji Shinkawa, Masahiko Kinoshita, Genya Hamano, Tokuji Ito, Masaki Koda, Takanori Aota, Takatsugu Yamamoto, Hiroaki Terajima, Gorou Tachiyama, Terumasa Yamada, Shoji Nakamori, Akira Arimoto, Masahiro Fujikawa, Yoshito Tomimaru, Yasuhiko Sugawara, Kei Nakagawa, Michiaki Unno, Toru Mizuguchi, Kenji Takenaka, Koichi Kimura, Ken Shirabe, Akio Saiura, Katsuhiko Uesaka, Hiroki Taniguchi, Akira Fukuda, Ja-Mun Chong, Yuko Kuwae, Masahiko Ohsawa, Yasunori Sato, Yasuni Nakanuma
• Journal: Journal of hepato-biliary-pancreatic sciences (J Hepatobiliary Pancreat Sci) Vol. 23 Issue 9 Pg. 556-64 (Sep 2016) ISSN: 1868-6982 [Electronic] Japan
• PMID: 27363864 (Publication Type: Journal Article)
• Copyright: © 2016 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

Chemical References

• Methylene Chloride

Topics

• Adult
• Bile Duct Neoplasms (chemically induced, pathology, surgery)
• Biliary Tract Surgical Procedures (methods, mortality)
• Biopsy, Needle
• Cholangiocarcinoma (chemically induced, pathology, surgery)
• Cohort Studies
• Disease-Free Survival
• Female
• Humans
• Immunohistochemistry
• Japan
• Male
• Methylene Chloride (adverse effects)
• Middle Aged
• Occupational Diseases (diagnosis, surgery)
• Occupational Exposure (adverse effects)
• Prognosis
• Retrospective Studies
• Risk Assessment
• Survival Rate
• Treatment Outcome