Abstract | BACKGROUND: Low cardiorespiratory fitness has been established as a risk factor for cardiovascular-related morbidity. However, research about the impact of fitness on lipid abnormalities, including atherogenic dyslipidemia, has produced mixed results. The purpose of this investigation is to examine the influence of baseline fitness and changes in fitness on the development of atherogenic dyslipidemia. METHODS: RESULTS: A total of 193 participants developed atherogenic dyslipidemia during an average of 8.85 years of follow-up. High baseline fitness was protective against the development of atherogenic dyslipidemia in comparison with those with low fitness (odds ratio [OR] 0.57; 95% confidence interval [CI], 0.37-0.89); however, this relationship became nonsignificant after controlling for baseline HDL-C, LDL-C, and TG levels. Participants who maintained fitness over time had lower odds of developing atherogenic dyslipidemia than those with a reduction in fitness (OR 0.56; 95% CI, 0.34-0.91) after adjusting for baseline confounders and changes in known risk factors. CONCLUSIONS: High fitness at baseline and maintenance of fitness over time are protective against the development of atherogenic dyslipidemia.
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Authors | Charity B Breneman, Kristen Polinski, Mark A Sarzynski, Carl J Lavie, Peter F Kokkinos, Ali Ahmed, Xuemei Sui |
Journal | The American journal of medicine
(Am J Med)
Vol. 129
Issue 10
Pg. 1060-6
(10 2016)
ISSN: 1555-7162 [Electronic] United States |
PMID | 27288861
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
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Topics |
- Adult
- Atherosclerosis
- Cardiorespiratory Fitness
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Dyslipidemias
(blood, epidemiology)
- Exercise Test
- Exercise Tolerance
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Triglycerides
(blood)
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