Synergism between sinusoidal-50 Hz magnetic field and formaldehyde in triggering carcinogenic effects in male Sprague-Dawley rats.

Abstract

BACKGROUND:

Experimental rodent bioassays performed up to now have failed to provide conclusive confirmation of the carcinogenicity of extremely low frequency magnetic fields (ELFMF).

OBJECTIVES:

To evaluate the potential synergistic carcinogenic effects of concurrent exposure to ELFMF and formaldehyde in four groups of male and female Sprague-Dawley rats.

METHODS:

One group was exposed from prenatal life until natural death to S-50 Hz MF and to formaldehyde in drinking water from 6 weeks of age for 104 weeks, two groups were treated only with formaldehyde or only with MF and one group served as untreated control.

RESULTS:

Compared to untreated controls, exposure to MF and formaldehyde causes in males a statistically significant increased incidence of malignant tumors (P ≤ 0.01), thyroid C-cell carcinomas (P ≤ 0.01), and hemolymphoreticular neoplasias (P ≤ 0.05). No statistically significant differences were observed among female groups.

CONCLUSIONS:

Life-span exposure to MF and formaldehyde induces statistically significant carcinogenic effects in male rats. Am. J. Ind. Med. 59:509-521, 2016. © 2016 Wiley Periodicals, Inc.

• Authors: Morando Soffritti, Eva Tibaldi, Michela Padovani, David G Hoel, Livio Giuliani, Luciano Bua, Michelina Lauriola, Laura Falcioni, Marco Manservigi, Fabiana Manservisi, Fiorella Belpoggi
• Journal: American journal of industrial medicine (Am J Ind Med) Vol. 59 Issue 7 Pg. 509-21 (07 2016) ISSN: 1097-0274 [Electronic] United States
• PMID: 27219869 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2016 Wiley Periodicals, Inc.

Chemical References

• Carcinogens
• Formaldehyde

Topics

• Animals
• Carcinogens
• Cocarcinogenesis
• Female
• Formaldehyde (adverse effects)
• Hematologic Neoplasms (etiology)
• Kaplan-Meier Estimate
• Leukemia (etiology)
• Lymphoma (etiology)
• Magnetic Fields (adverse effects)
• Male
• Rats
• Rats, Sprague-Dawley
• Sex Factors
• Thyroid Neoplasms (etiology, pathology)