Polydopamine Nanoparticles as a Versatile Molecular Loading Platform to Enable Imaging-guided Cancer Combination Therapy.

Abstract

Cancer combination therapy to treat tumors with different therapeutic approaches can efficiently improve treatment efficacy and reduce side effects. Herein, we develop a theranostic nano-platform based on polydopamine (PDA) nanoparticles, which then are exploited as a versatile carrier to allow simultaneous loading of indocyanine green (ICG), doxorubicin (DOX) and manganese ions (PDA-ICG-PEG/DOX(Mn)), to enable imaging-guided chemo & photothermal cancer therapy. In this system, ICG acts as a photothermal agent, which shows red-shifted near-infrared (NIR) absorbance and enhanced photostability compared with free ICG. DOX, a model chemotherapy drug, is then loaded onto the surface of PDA-ICG-PEG with high efficiency. With Mn(2+) ions intrinsically chelated, PDA-ICG-PEG/DOX(Mn) is able to offer contrast under T1-weighted magnetic resonance (MR) imaging. In a mouse tumor model, the MR imaging-guided combined chemo- & photothermal therapy achieves a remarkable synergistic therapeutic effect compared with the respective single treatment modality. This work demonstrates that PDA nanoparticles could serve as a versatile molecular loading platform for MR imaging guided combined chemo- & photothermal therapy with minimal side effects, showing great potential for cancer theranostics.

• Authors: Ziliang Dong, Hua Gong, Min Gao, Wenwen Zhu, Xiaoqi Sun, Liangzhu Feng, Tingting Fu, Yonggang Li, Zhuang Liu
• Journal: Theranostics (Theranostics) Vol. 6 Issue 7 Pg. 1031-42 ( 2016) ISSN: 1838-7640 [Electronic] Australia
• PMID: 27217836 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Coloring Agents
• Drug Carriers
• Indoles
• Polymers
• Trace Elements
• polydopamine
• Manganese
• Doxorubicin
• Indocyanine Green

Topics

• Animals
• Antineoplastic Agents (administration & dosage)
• Breast Neoplasms (diagnostic imaging, drug therapy)
• Cell Line, Tumor
• Coloring Agents (administration & dosage)
• Combined Modality Therapy (methods)
• Disease Models, Animal
• Doxorubicin (administration & dosage)
• Drug Carriers (administration & dosage)
• Drug Therapy, Combination
• Heterografts
• Humans
• Hyperthermia, Induced
• Indocyanine Green (administration & dosage)
• Indoles (administration & dosage)
• Magnetic Resonance Imaging
• Manganese (administration & dosage)
• Mice, Inbred BALB C
• Nanoparticles (administration & dosage)
• Phototherapy
• Polymers (administration & dosage)
• Staining and Labeling (methods)
• Trace Elements (administration & dosage)
• Treatment Outcome