Abstract |
A series of novel chalcone-1,2,3-triazole-azole hybrids were designed, synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (SK-N-SH, EC-109 and MGC-803). Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. Particularly, compound I-21 showed the most excellent antiproliferative activity with an IC50 value of 1.52 μM against SK-N-SH cancer cells. Further mechanism studies revealed that compound I-21 induced morphological changes of SK-N-SH cancer cells possibly by inducing apoptosis. Novel chalcone-1,2,3-triazole-azole derivatives in this work might be a series of promising lead compounds to develop anticancer agents for treating neuroblastoma.
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Authors | Sai-Yang Zhang, Dong-Jun Fu, Xiao-Xin Yue, Ying-Chao Liu, Jian Song, Hui-Hui Sun, Hong-Min Liu, Yan-Bing Zhang |
Journal | Molecules (Basel, Switzerland)
(Molecules)
Vol. 21
Issue 5
(May 19 2016)
ISSN: 1420-3049 [Electronic] Switzerland |
PMID | 27213317
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Azoles
(chemistry, pharmacology)
- Cell Line, Tumor
- Humans
- Structure-Activity Relationship
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