Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis.

Abstract

A study has been carried out of the volatile organic compounds present in the exhaled breath of 58 cystic fibrosis (CF) patients. An important observation is that the acetic acid vapour concentration measured by selected ion flow tube mass spectrometry (SIFT-MS) is significantly elevated in the exhaled breath of CF patients, independent of the Pseudomonas aeruginosa (PA) infection status (PA-infected median 170 ppbv; PA-negative median 182 ppbv), compared to that of healthy controls (median 48 ppbv). The cause for this may be decreased pH of the mucus lining the CF airways. Thus, we speculate that non-invasive measurement of breath acetic acid concentration could serve as an indicator of the acidity of the CF airways mucosa.

• Authors: David Smith, Kristýna Sovová, Kseniya Dryahina, Tereza Doušová, Pavel Dřevínek, Patrik Španěl
• Journal: Journal of breath research (J Breath Res) Vol. 10 Issue 2 Pg. 021002 (May 17 2016) ISSN: 1752-7163 [Electronic] England
• PMID: 27184114 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Acetic Acid

Topics

• Acetic Acid (analysis)
• Adolescent
• Adult
• Biomarkers (analysis)
• Breath Tests (methods)
• Child
• Child, Preschool
• Cystic Fibrosis (complications, physiopathology)
• Exhalation
• Female
• Humans
• Male
• Mass Spectrometry
• Pseudomonas Infections (complications, physiopathology)
• Pseudomonas aeruginosa
• Young Adult