The clinical pathological significance of Thy1 and CD49f expression in chondrosarcomas.

Abstract

OBJECTIVE:

This study investigated the protein expression and clinicopathological significance of Thy1 and CD49f in chondrosarcomas.

METHODS:

Thy1 and CD49f protein expression in 59 chondrosarcomas and 33 osteochondromas were measured by immunohistochemical staining.

RESULTS:

The percentage of positive Thy1 and CD49f expression was significantly higher in patients with chondrosarcoma than in patients with osteochondroma (P<0.01). The percentage of positive Thy1 and CD49f expression was significantly lower in patients with histological grade I, Enneking stage I, AJCC stage I/II stage, non-metastatic and non-invasive chondrosarcoma than in patients with histological grade III, Enneking stage II+III, AJCC stage III/IV, metastatic and invasive chondrosarcoma (P<0.05 or P<0.01). Thy1 expression was positively correlated with CD49f expression in chondrosarcoma. Kaplan-Meier survival analysis showed that histological grade, AJCC stage, Enneking stage, metastasis, invasion, and Thy1 and CD49f expression significantly correlated with shorter mean survival time in chondrosarcoma patients (P<0.05 or P<0.01). Cox multivariate analysis showed that positive Thy1 and CD49f expression was an independent prognostic factor that negatively correlated with overall postoperative survival.

CONCLUSION:

Positive Thy1 and CD49f expression is significantly associated with the progression and poor prognosis of chondrosarcoma.

• Authors: Lile He, Zhulin Yang, Zhihong Li
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 212 Issue 7 Pg. 636-42 (Jul 2016) ISSN: 1618-0631 [Electronic] Germany
• PMID: 27155928 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier GmbH. All rights reserved.

Chemical References

• Integrin alpha6
• Thy-1 Antigens

Topics

• Adult
• Bone Neoplasms (metabolism, mortality, pathology)
• Chondrosarcoma (metabolism, mortality, pathology)
• Disease Progression
• Female
• Humans
• Immunohistochemistry
• Integrin alpha6 (metabolism)
• Male
• Middle Aged
• Neoplasm Staging
• Osteochondroma (metabolism, mortality, pathology)
• Prognosis
• Survival Rate
• Thy-1 Antigens (metabolism)