Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour.

Abstract

OBJECTIVE:

To investigate the immunohistochemical localization of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) in archival specimens of sporadic schwannoma.

METHOD:

This study retrospectively analysed the immunolocalization of IGF-1 and IGF-1R in schwannoma specimens collected from all patients with sporadic schwannoma that were treated by two institutions in Japan. The study also evaluated the association between the extent of the IGF-1 and IGF-1R immunoreactivity and several clinicopathological characteristics (age, sex and maximum tumour dimension).

RESULTS:

The study examined a total of 29 sporadic schwannoma specimens. IGF-1 and IGF-1R immunoreactivity was detected in the majority of the specimens regardless of their anatomical location. IGF-1 and IGF-1R were not co-localized. There was no association between the extent of the IGF-1 and IGF-1R immunoreactivity and the clinicopathological characteristics of the patients.

CONCLUSIONS:

As IGF-1 and IGF-1R immunoreactivity was detected in the majority of sporadic schwannoma specimens regardless of their anatomical location, these findings suggest that an IGF-1/IGF-1R loop could play a role in the tumorigenesis and progression of schwannomas via an autocrine-paracrine mechanism.

• Authors: Fumiaki Matsubara, Takuyuki Katabami, Shiko Asai, Yasushi Ariizumi, Ichiro Maeda, Masayuki Takagi, May McNamara Keely, Katsuhiko Ono, Takashi Maekawa, Yasuhiro Nakamura, Yasushi Tanaka, Hironobu Sasano
• Journal: The Journal of international medical research (J Int Med Res) Vol. 44 Issue 3 Pg. 662-72 (Jun 2016) ISSN: 1473-2300 [Electronic] England
• PMID: 27091859 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2016.

Chemical References

• Insulin-Like Growth Factor I
• Receptor, IGF Type 1

Topics

• Demography
• Female
• Humans
• Immunohistochemistry
• Insulin-Like Growth Factor I (metabolism)
• Male
• Middle Aged
• Nerve Sheath Neoplasms (metabolism, pathology)
• Neurilemmoma (metabolism, pathology)
• Receptor, IGF Type 1 (metabolism)
• Retroperitoneal Neoplasms (metabolism, pathology)