Abstract |
To evaluate the efficacy and safety of the chemotherapy program of docetaxel combined with lobaplatin for Chinese patients with pulmonary and hepatic metastasis of nasopharyngeal carcinoma (NPC). This study included 37 NPC patients with pulmonary and hepatic metastasis. The chemotherapy program included docetaxel (75 mg/m, day 1) plus lobaplatin (30 mg/m, day 1). Cycle repetition was every 21 days. Patients were monitored for 7-41 months, with a median follow-up duration of 18 months. The total efficiency of this group was 67.6% and the disease control rate was 81.1%. The median progression-free survival was 9.4 months (95% confidence interval, 6.8-14.3 months), the median overall survival was 18.3 months (95% confidence interval, 13.7-22.8 months), and the 2-year survival rate was 37.8%. The main hematological toxicities were leukopenia (91.9%), anemia (81.1%), and thrombocytopenia (70.3%); other adverse reactions were mild. Changes in Epstein-Barr- DNA levels can basically reflect the dynamic changes in the efficacy of chemotherapy. Docetaxel combined with lobaplatin has a favorable outcome for the treatment of pulmonary and hepatic metastatic NPC. It has been a convenient regimen with tolerable toxicity.
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Authors | Shuai Zhang, Junni Chen, Shiping Yang, Shaomin Lin |
Journal | Anti-cancer drugs
(Anticancer Drugs)
Vol. 27
Issue 7
Pg. 685-8
(08 2016)
ISSN: 1473-5741 [Electronic] England |
PMID | 27088576
(Publication Type: Clinical Trial, Phase II, Journal Article)
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Chemical References |
- Cyclobutanes
- Organoplatinum Compounds
- Taxoids
- Docetaxel
- lobaplatin
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Carcinoma
(drug therapy, pathology)
- Cyclobutanes
(administration & dosage, adverse effects)
- Docetaxel
- Female
- Humans
- Liver Neoplasms
(drug therapy, secondary)
- Lung Neoplasms
(drug therapy, secondary)
- Male
- Middle Aged
- Nasopharyngeal Carcinoma
- Nasopharyngeal Neoplasms
(drug therapy, pathology)
- Organoplatinum Compounds
(administration & dosage, adverse effects)
- Taxoids
(administration & dosage, adverse effects)
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