Clinical effect of intravitreous injection of triamcinolone acetonide in treating cystoid macular edema.

Abstract

Cystoid macular edema (CME), a commonly seen sign for multiple fundus diseases, is able to induce visual deterioration. The incidence rate of CME is constantly increasing; however, the existing clinical treatments cannot achieve satisfactory curative effects. To explore the curative effect of intravitreous injection of triamcinolone acetonide (TA) in treating CME, this study carried out a clinical test on 39 patients (42 eyes) from The First Affiliated Hospital of Zhengzhou University who developed CME induced by central retinal vein occlusion (CRVO). All 42 eyes received intravitreous injection of 40 mg/ml TA (0.1 ml) and then were followed up for 11-23.5 months. Eyes were examined by slit-lamp microscope, fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) and best corrected visual acuity (BCVA), and intraocular pressure (IOP) of those eyes were detected before and after treatment. Average vision of eyes was 0.1 before treatment, and the vision improved in one month (vision ≥ 0.2: 100%; vision ≥ 0.5: 42.9%) and three months (vision ≥ 0.2: 64.3%; vision ≥ 0.5: 21.4%) after treatment; but as time went on, the vision of some patients declined; at the last follow-up, patients with vision ≥ 0.2 accounted for 28.6% and those with vision ≥0.5 accounted for 7.1%; compared to before treatment, 71.4% patients had improved vision and the remaining 28.6% had declined vision. Some patients were observed with high IOP during treatment, and 7 eyes were found with secondary cataract in posterior capsule of lens at the last follow-up. Intravitreous injection of triamcinolone acetonide proved to have significant short-term curative effect on CEM which is non-sensitive to conventional therapies, but it is likely to induce high IPO and posterior capsular opacification.

• Authors: P S Yan, C Qian, G M Wan, W Z Wang, Y Dong, F Z Li
• Journal: Journal of biological regulators and homeostatic agents (J Biol Regul Homeost Agents) 2016 Jan-Mar Vol. 30 Issue 1 Pg. 205-10 ISSN: 0393-974X [Print] Italy
• PMID: 27049093 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Triamcinolone Acetonide

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Fluorescein Angiography
• Humans
• Macular Edema (diagnostic imaging, drug therapy, physiopathology)
• Male
• Middle Aged
• Radiography
• Tomography, Optical Coherence
• Triamcinolone Acetonide (administration & dosage, adverse effects, therapeutic use)
• Vision, Ocular
• Young Adult