Postoperative AMH reduction is not associated with reduced fecundity two years following ovarian cyst surgery.

Abstract

In a prospective study, we investigated the impact of anti-Müllerian hormone (AMH) changes following ovarian cyst surgery on the probability to achieve pregnancy and live birth. Women of reproductive age (n = 60) were included before surgery for benign ovarian cysts. Serum AMH concentrations were determined pre- and postoperative at 6 and 24 months. Information regarding pregnancy wish and attempts to conceive were obtained by a questionnaire. At the time of inclusion, 45/60 women reported desire of children. At six months, the levels of AMH decreased significantly in the whole group and further reduction was observed at two years (from 2.7 μg/L to 2.0 μg/L to 1.1 μg/L, respectively, p<  0.008), with a percentage reduction of 42.9%. At two-year follow-up, 36 women reported to have attempted to conceive and 18 achieved pregnancy (50%), with a live birth rate of 33%. The percentage change in AMH at two years did not differ significantly between the women who conceived versus those who did not (p = 0.117). Data reported herein demonstrate that the AMH reduction following ovarian cyst surgery is maintained two years after surgery; however, the postoperative AMH decrease that follows ovarian cyst surgery might not reduce the chances to achieve pregnancy.

• Authors: Tekla Lind, Claudia Lampic, Jan I Olofsson, Kenny A Rodriguez-Wallberg
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 32 Issue 9 Pg. 745-748 (Sep 2016) ISSN: 1473-0766 [Electronic] England
• PMID: 27028572 (Publication Type: Journal Article)

Chemical References

• Anti-Mullerian Hormone

Topics

• Adult
• Anti-Mullerian Hormone (blood)
• Female
• Fertility
• Humans
• Live Birth
• Ovarian Cysts (surgery)
• Postoperative Period
• Pregnancy
• Prospective Studies
• Young Adult