Abstract | OBJECTIVE: PARTICIPANTS: A total of 64 214 Medicare beneficiaries aged 65 years or older meeting inclusion criteria and hospitalized with a TBI during 2006 to 2010. DESIGN: New user design. Generalized estimating equations were used to estimate the relative risks (RRs) of stroke. MAIN MEASURES: Primary exposure was new antidepressant use following TBI identified through Medicare part D claims. The primary outcome was stroke following TBI. Ischemic and hemorrhagic strokes were secondary outcomes. RESULTS: CONCLUSION: Findings from this study will aid prescribers in choosing appropriate antidepressants to treat depression in older adults with TBI.
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Authors | Bilal Khokhar, Linda Simoni-Wastila, Jennifer S Albrecht |
Journal | The Journal of head trauma rehabilitation
(J Head Trauma Rehabil)
2017 Jan/Feb
Vol. 32
Issue 1
Pg. E42-E49
ISSN: 1550-509X [Electronic] United States |
PMID | 27022963
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Antidepressive Agents
(adverse effects, therapeutic use)
- Brain Injuries, Traumatic
(complications, diagnosis, therapy)
- Case-Control Studies
- Confidence Intervals
- Depression
(drug therapy, etiology, physiopathology)
- Female
- Follow-Up Studies
- Geriatric Assessment
(methods)
- Hospitalization
(statistics & numerical data)
- Humans
- Incidence
- Length of Stay
- Male
- Medicare
(statistics & numerical data)
- Retrospective Studies
- Severity of Illness Index
- Stroke
(chemically induced, epidemiology, physiopathology)
- Survival Rate
- United States
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