Plasma/Serum Leptin Levels in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-analysis.

Abstract

BACKGROUND AND AIMS:

Leptin is an adipokine that has several effects on metabolism and immune system in patients with ankylosing spondylitis (AS). The present investigations of the relationship between plasma/serum leptin levels and AS are contradictory. To derive a more precise estimation on the plasma/serum leptin levels in AS patients and related factors, a meta-analysis was performed.

METHODS:

Published literature that compares plasma/serum leptin levels between AS group and control group from PubMed, Embase, Cochrane Library and other databases were searched. The study quality was assessed by the Newcastle-Ottawa scale. Pooled standardized mean difference (SMD) with its 95% confidence interval (CI) was calculated by fixed-effects or random-effect model analyses. Statistical heterogeneity within studies was examined by the Q statistic.

RESULTS:

A total of eight studies including 391 AS patients and 293 healthy controls were finally included in the meta-analysis. No significant differences in plasma/serum leptin levels was found between AS patients and healthy controls when all studies were pooled into the meta-analysis (pooled SMD = 0.384, 95% CI = -1.522 to 0.753). Meanwhile, subgroup analyses by gender also showed no significant differences in plasma/serum leptin levels between case group and controls.

CONCLUSION:

There is no significant difference in plasma/serum leptin levels between AS patients and controls.

• Authors: Yong-Jun Mei, Peng Wang, Lin-Jie Chen, Zhi-Jun Li
• Journal: Archives of medical research (Arch Med Res) Vol. 47 Issue 2 Pg. 111-7 (02 2016) ISSN: 1873-5487 [Electronic] United States
• PMID: 27016486 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
• Copyright: Copyright © 2016 IMSS. Published by Elsevier Inc. All rights reserved.

Chemical References

• Adipokines
• Leptin

Topics

• Adipokines
• Case-Control Studies
• Humans
• Leptin (blood)
• Plasma
• Serum
• Spondylitis, Ankylosing (blood)