Caveolae and Caveolin-1 Integrate Reverse Cholesterol Transport and Inflammation in Atherosclerosis.

Abstract

Lipid disorder and inflammation play critical roles in the development of atherosclerosis. Reverse cholesterol transport is a key event in lipid metabolism. Caveolae and caveolin-1 are in the center stage of cholesterol transportation and inflammation in macrophages. Here, we propose that reverse cholesterol transport and inflammation in atherosclerosis can be integrated by caveolae and caveolin-1.

• Authors: Li Qin, Neng Zhu, Bao-Xue Ao, Chan Liu, Ya-Ning Shi, Ke Du, Jian-Xiong Chen, Xi-Long Zheng, Duan-Fang Liao
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 17 Issue 3 Pg. 429 (Mar 22 2016) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 27011179 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Caveolin 1
• Cholesterol

Topics

• Animals
• Atherosclerosis (metabolism)
• Biological Transport, Active
• Caveolae (metabolism)
• Caveolin 1 (metabolism)
• Cholesterol (metabolism)
• Humans
• Inflammation (metabolism)