Effect of food and acid-reducing agents on the absorption of oral targeted therapies in solid tumors.

Abstract

Oral targeted therapies represent an increasingly important group of drugs within modern oncology. With the shift from intravenously to orally administered drugs, drug absorption is a newly introduced factor in drug disposition. The process of absorption can have a large effect on inter- and intrasubject variability in drug exposure and thereby potentially treatment benefit or the severity of toxicities. The intake of oral targeted therapies with food and concomitant use of acid-reducing agents (ARAs) can significantly affect drug absorption. The size and direction of the effect of food and ARAs on drug absorption varies among drugs as a result of different chemical characteristics. Therefore, an awareness and understanding of these effects for each drug is essential to optimize patient outcomes.

• Authors: Annelieke E C A B Willemsen, Floor J E Lubberman, Jolien Tol, Winald R Gerritsen, Carla M L van Herpen, Nielka P van Erp
• Journal: Drug discovery today (Drug Discov Today) Vol. 21 Issue 6 Pg. 962-76 (06 2016) ISSN: 1878-5832 [Electronic] England
• PMID: 26995271 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Histamine H2 Antagonists
• Proton Pump Inhibitors

Topics

• Administration, Oral
• Antineoplastic Agents (pharmacokinetics)
• Biological Availability
• Food-Drug Interactions
• Histamine H2 Antagonists (pharmacology)
• Humans
• Intestinal Absorption (drug effects)
• Neoplasms (metabolism)
• Proton Pump Inhibitors (pharmacology)