5-Caffeoylquinic acid inhibits invasion of non-small cell lung cancer cells through the inactivation of p70S6K and Akt activity: Involvement of p53 in differential regulation of signaling pathways.

Abstract

In the present study, we investigated the effects and molecular mechanism of 5-caffeoylquinic acid (5-CQA), a natural phenolic compound isolated from Ligularia fischeri, on cell invasion, proliferation and adhesion in p53 wild-type A549 and p53-deficient H1299 non-small cell lung cancer (NSCLC) cells. 5-CQA abrogated mitogen-stimulated invasion, but not proliferation, in both A549 and H1299 cells. In addition, 5-CQA inhibited mitogen-stimulated adhesion in A549 cells only. Anti-invasive activity of 5-CQA in A549 cells was mediated by the inactivation of p70(S6K)-dependent signaling pathway. In contrast, in H1299 cells the inactivation of Akt was found to be involved in 5-CQA-mediated inhibition of cell invasion. Collectively, these findings demonstrate the pharmacological roles and molecular targets of 5-CQA in regulating NSCLC cell fate, and suggest further evaluation and development of 5-CQA as a potential therapeutic agent for the treatment and prevention of lung cancer.

• Authors: Jae-Kyung In, Jin-Kyu Kim, Joa Sub Oh, Dong-Wan Seo
• Journal: International journal of oncology (Int J Oncol) Vol. 48 Issue 5 Pg. 1907-12 (May 2016) ISSN: 1791-2423 [Electronic] Greece
• PMID: 26984670 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• TP53 protein, human
• Tumor Suppressor Protein p53
• caffeoylquinic acid
• Quinic Acid
• Proto-Oncogene Proteins c-akt
• Ribosomal Protein S6 Kinases, 70-kDa

Topics

• Carcinoma, Non-Small-Cell Lung (drug therapy, metabolism)
• Cell Line, Tumor
• Cell Movement (drug effects)
• Cell Proliferation (drug effects)
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Lung Neoplasms (drug therapy, metabolism)
• Neoplasm Invasiveness
• Proto-Oncogene Proteins c-akt (metabolism)
• Quinic Acid (analogs & derivatives, pharmacology)
• Ribosomal Protein S6 Kinases, 70-kDa (metabolism)
• Signal Transduction (drug effects)
• Tumor Suppressor Protein p53 (metabolism)