SUVmax on FDG-PET is a predictor of prognosis in patients with maxillary sinus cancer.

Abstract

PURPOSE:

Our aim was to determine whether the maximum standardized uptake value (SUVmax) of the primary lesion demonstrated by [(18)F]-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is associated with the prognosis of maxillary sinus cancer.

MATERIALS AND METHODS:

The relationships of clinicopathological factors including age, T stage, N stage, histologic type, treatment strategy, and primary tumor SUVmax with progression-free (PFS) and overall (OS) survival were evaluated using the log-rank test and Cox method in 31 patients with maxillary sinus cancer before combined superselective intra-arterial chemotherapy using high-dose cisplatin with concurrent radiotherapy, or radiotherapy alone.

RESULTS:

The median duration of follow-up was 55.4 (range 9.7-72.6) months. PFS and OS of patients exhibiting a high SUVmax (≥16 and ≥17, respectively) for the primary tumor were significantly lower than those of patients for whom the primary tumor SUVmax was low (p = 0.0010 and p = 0.033, respectively). Multivariate analyses showed that T stage (p = 0.0049) and primary tumor SUVmax (p = 0.026) were independently prognostic of poorer PFS and that only primary tumor SUVmax (p = 0.049) was independently prognostic of poorer OS.

CONCLUSION:

SUVmax of the primary tumor determined by FDG-PET/CT before treatment could be a good surrogate marker for prognostication of maxillary sinus cancer.

• Authors: Hiroshi Doi, Kazuhiro Kitajima, Kazuhito Fukushima, Yusuke Kawanaka, Miya Mouri, Satoshi Yamamoto, Reiichi Ishikura, Tomonori Terada, Kazuma Noguchi, Shozo Hirota
• Journal: Japanese journal of radiology (Jpn J Radiol) Vol. 34 Issue 5 Pg. 349-55 (May 2016) ISSN: 1867-108X [Electronic] Japan
• PMID: 26920841 (Publication Type: Journal Article)

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Follow-Up Studies
• Humans
• Male
• Maxillary Sinus (diagnostic imaging)
• Maxillary Sinus Neoplasms (diagnostic imaging)
• Middle Aged
• Positron-Emission Tomography (methods)
• Prognosis
• ROC Curve
• Radiopharmaceuticals (pharmacokinetics)
• Reproducibility of Results
• Retrospective Studies