Abstract | BACKGROUND: METHODS: We retrospectively identified 39 patients who underwent CRS + HIPEC with splenectomy during a 3-year study period from a prospective database. We compared them to case controls (CRS + HIPEC without splenectomy) that were matched for the complexity of the procedure. We evaluated the complication rate and outcomes of patients in each group. RESULTS: During the study period, splenectomy was performed in 32 % of patients undergoing CRS + HIPEC procedure. Patients in the splenectomy group experienced more grade 3-4 complications than patients in the control group (59 vs. 35.9 %, p = 0.041) as well as more pulmonary complications (41 vs. 7.7 %, p = 0.0006). Multivariate analysis identified splenectomy as the only predictor of overall major complications (odds ratio = 2.57, 95 % confidence interval = 1.03-6.40). Mortality was similar in both groups. CONCLUSIONS:
Splenectomy increases major complication rate in patients undergoing CRS + HIPEC and efforts should be made to preserve the spleen during the surgery.
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Authors | Francois Dagbert, Remy Thievenaz, Evelyne Decullier, Naoual Bakrin, Eddy Cotte, Pascal Rousset, Delphine Vaudoyer, Guillaume Passot, Olivier Glehen |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 23
Issue 6
Pg. 1980-5
(06 2016)
ISSN: 1534-4681 [Electronic] United States |
PMID | 26913716
(Publication Type: Journal Article)
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Chemotherapy, Cancer, Regional Perfusion
(adverse effects)
- Combined Modality Therapy
- Cytoreduction Surgical Procedures
(adverse effects)
- Female
- Follow-Up Studies
- Humans
- Hyperthermia, Induced
(adverse effects)
- Male
- Middle Aged
- Neoplasms
(pathology, therapy)
- Peritoneal Neoplasms
(pathology, therapy)
- Postoperative Complications
(etiology)
- Prognosis
- Prospective Studies
- Retrospective Studies
- Splenectomy
(adverse effects)
- Survival Rate
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