Role of Hydrogen Sulfide in Systemic and Pulmonary Hypertension: Cellular Mechanisms and Therapeutic Implications.

Abstract

There is increasing interest in the possible therapeutic benefits of the gasotransmitter hydrogen sulfide (H2S sulfide), and drugs which release sulfide are currently being evaluated in both preclinical and clinical studies as treatments for conditions ranging from cancer to cardiovascular disease to inflammation. Sulfide is generally considered to act as a vasodilator, and it is therefore not surprising that the effects of sulfide donors on both systemic and pulmonary hypertension are being examined. In this review, we provide a critical evaluation of both the evidence that H2S may be of benefit in treating systemic and pulmonary hypertension, and of current hypotheses regarding the cellular mechanisms underlying sulfide's effects on the systemic and pulmonary vascular systems.

• Authors: Joshua Brampton, Philip I Aaronson
• Journal: Cardiovascular & hematological agents in medicinal chemistry (Cardiovasc Hematol Agents Med Chem) Vol. 14 Issue 1 Pg. 4-22 ( 2016) ISSN: 1875-6182 [Electronic] Netherlands
• PMID: 26830724 (Publication Type: Journal Article, Review)

Chemical References

• Potassium Channels
• Vasodilator Agents
• Nitric Oxide
• Hydrogen Sulfide

Topics

• Animals
• Humans
• Hydrogen Sulfide (metabolism, therapeutic use)
• Hypertension (drug therapy, metabolism)
• Hypertension, Pulmonary (drug therapy, metabolism)
• Nitric Oxide (metabolism)
• Potassium Channels (metabolism)
• Signal Transduction (drug effects)
• Vasodilator Agents (metabolism, therapeutic use)