Abstract | BACKGROUND: OBJECTIVE: The aim of this study was to evaluate the efficacy and time to conversion to SR of transplacental treatment, especially flecainide. METHODS: This is a retrospective observational study of 46 fetuses with fetal tachyarrhythmia. Treatment was either flecainide (n = 28, 60.9%), digoxin+flecainide combination (n = 4, 8.7%), or digoxin (n = 10, 21.7%). In 4 fetuses (8.7%), no treatment was necessary. RESULTS: In our study population, 26 of the 32 fetuses (81.2%) that were treated with flecainide as a first-line therapy ( flecainide or digoxin+flecainide) converted to SR. The median time to conversion to SR was 3 days (range 1-7 days) with flecainide monotherapy and 11.5 days (range 3-14 days) with a combination therapy. Seventy-two percent (13/18) of hydropic fetuses and 90% (9/10) of nonhydropic fetuses converted to SR when treated with flecainide monotherapy. There was no statistical difference in rates of conversion to SR in hydropic and nonhydropic fetuses (P = .37) or time to conversion to SR in the 2 groups (P = .9). In the majority of the remaining fetuses, there was a partial response with decreased ventricular heart rates that were well tolerated. CONCLUSION:
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Authors | Brigitte Strizek, Christoph Berg, Ingo Gottschalk, Ulrike Herberg, Annegret Geipel, Ulrich Gembruch |
Journal | Heart rhythm
(Heart Rhythm)
Vol. 13
Issue 6
Pg. 1283-8
(06 2016)
ISSN: 1556-3871 [Electronic] United States |
PMID | 26829115
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Arrhythmia Agents
- Digoxin
- Flecainide
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Topics |
- Adult
- Anti-Arrhythmia Agents
(administration & dosage)
- Digoxin
(administration & dosage)
- Female
- Flecainide
(administration & dosage)
- Heart Rate, Fetal
(drug effects)
- Humans
- Hydrops Fetalis
(physiopathology)
- Pregnancy
- Pregnancy Complications, Cardiovascular
(diagnosis, drug therapy, etiology)
- Retrospective Studies
- Tachycardia, Supraventricular
(diagnosis, drug therapy, etiology)
- Treatment Outcome
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