Abstract | PURPOSE: To report outcomes of postoperative radiotherapy (PORT) for major salivary gland carcinoma (SGC) and identify patients at high risk of distant metastases (DM). METHODS AND MATERIALS: Patients with major SGC treated between 2000-2012 were identified. All patients underwent initial primary resection, with neck dissection (ND) therapeutically (if N+) or electively in high risk N0 patients. PORT was delivered using 3D-CRT or IMRT. Multivariable analysis (MVA) assessed predictors for DM, cause-specific (CSS) and overall survival. RESULTS: Overall 304 patients were identified: 48% stage III-IVB, 22% lymphovascular invasion (LVI), 50% involved margins and 64% high risk pathology. ND was performed in 154 patients (51%). Adjuvant chemotherapy was used in 10 patients (3%). IMRT was delivered in 171 patients (56%) and 3D-CRT in 133 (44%). With a median follow-up of 82 months, the 5-(10-) year local, regional, distant control, CSS and OS were 96% (96%), 95% (94%), 80% (77%), 83% (82%) and 78% (75%), respectively. DM was the most frequent treatment failure (n=62). On MVA, stage III-IVB and LVI significantly correlated with DM, CSS and OS, while positive margins predicted DM and CSS, and high risk pathology predicted DM. No grade ⩾ 4 RTOG late toxicity was reported; 9 patients had grade 3, including osteoradionecrosis (n=4), neck fibrosis (n=3), trismus (n=1) and dysphagia (n=1). CONCLUSIONS: Surgery and PORT with 3D-CRT/IMRT produced excellent long-term outcomes. Further research is required for patients with stage III-IVB, LVI, positive margins and high risk pathology to determine the incremental benefit of systemic therapy in management of SGC.
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Authors | Ali Hosni, Shao Hui Huang, David Goldstein, Wei Xu, Biu Chan, Aaron Hansen, Ilan Weinreb, Scott V Bratman, John Cho, Meredith Giuliani, Andrew Hope, John Kim, Brian O'Sullivan, John Waldron, Jolie Ringash |
Journal | Oral oncology
(Oral Oncol)
Vol. 54
Pg. 75-80
(Mar 2016)
ISSN: 1879-0593 [Electronic] England |
PMID | 26723908
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Combined Modality Therapy
(methods)
- Disease-Free Survival
- Female
- Humans
- Male
- Middle Aged
- Models, Statistical
- Prognosis
- Radiotherapy Dosage
- Radiotherapy, Conformal
(methods)
- Radiotherapy, Intensity-Modulated
(methods)
- Retrospective Studies
- Salivary Gland Neoplasms
(pathology, radiotherapy, surgery)
- Salivary Glands
(pathology)
- Young Adult
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