High-Level Expression and Prognostic Significance of Matrix Metalloprotease-19 and Matrix Metalloprotease-20 in Human Pancreatic Ductal Adenocarcinoma.

Abstract

OBJECTIVE:

Matrix metalloproteinase (MMP)-19 and MMP-20 are important members of the MMP family, and their roles in tumor survivorship and progression are continually reported. This work aimed to determine the expression and prognostic significance of MMP-19 and MMP-20 in pancreatic ductal adenocarcinoma (PDAC).

METHODS:

Immunohistochemistry was used to investigate the levels of MMP-19 and MMP-20 expression in carcinoma tissues and paracancerous tissues from 102 PDAC patients.

RESULTS:

The MMP-19 and MMP-20 were, respectively, expressed in 71.6% (73/102) and 70.6% (72/102) of carcinoma tissues, and the expression was positively correlated (r = 0.643, P < 0.001). High-level expression of MMP-19 and MMP-20 was strongly correlated with aggressive clinicopathological characteristics. Kaplan-Meier analysis showed that high-level expression of MMP-19 and MMP-20 was significantly associated with decreased event-free survival (P < 0.001) and overall survival (P < 0.001). Multivariate analysis showed that high-level expression of MMP-19 could act as an independent predictive biomarker for poor event-free survival and overall survival.

CONCLUSIONS:

Levels of MMP-19 and MMP-20 expression are significantly increased in PDAC. High-level expression of MMP-19 and MMP-20 is closely correlated to progression and prognosis of PDAC, and these may be considered as promising markers for unfavorable prognoses.

• Authors: Lu-Lu Zhai, Yang Wu, Chong-Yang Cai, Qiang Huang, Zhi-Gang Tang
• Journal: Pancreas (Pancreas) Vol. 45 Issue 7 Pg. 1067-72 (08 2016) ISSN: 1536-4828 [Electronic] United States
• PMID: 26692439 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Matrix Metalloproteinase 20
• Matrix Metalloproteinases, Secreted
• matrix metalloproteinase 19

Topics

• Biomarkers, Tumor (biosynthesis)
• Carcinoma, Pancreatic Ductal (metabolism, pathology)
• Disease Progression
• Female
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Male
• Matrix Metalloproteinase 20 (biosynthesis)
• Matrix Metalloproteinases, Secreted (biosynthesis)
• Middle Aged
• Multivariate Analysis
• Pancreas (enzymology, pathology)
• Pancreatic Neoplasms (metabolism, pathology)
• Prognosis