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Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer.

AuthorsNancy J Ganson, Thomas J Povsic, Bruce A Sullenger, John H Alexander, Steven L Zelenkofske, Jeffrey M Sailstad, Christopher P Rusconi, Michael S Hershfield
JournalThe Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 137 Issue 5 Pg. 1610-1613.e7 (05 2016) ISSN: 1097-6825 [Electronic] United States
PMID26688515 (Publication Type: Letter, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticoagulants
  • Aptamers, Nucleotide
  • Immunoglobulin G
  • RB 006
  • Polyethylene Glycols
Topics
  • Anticoagulants (adverse effects, immunology)
  • Aptamers, Nucleotide (adverse effects, immunology)
  • Drug Hypersensitivity (diagnosis, immunology)
  • Enzyme-Linked Immunosorbent Assay
  • Follow-Up Studies
  • Humans
  • Immunoglobulin G (immunology)
  • Polyethylene Glycols

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