Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis.

Abstract

Hypertension and cerebral amyloid angiopathy (CAA) are major risk factors for intracerebral hemorrhage (ICH); however the mechanisms of interplay between the two are not fully understood. We investigated the effect of hypertension in a transgenic mouse model with Alzheimer's-like pathology (Tg2576) treating them with angiotensin II and L-N(G)-nitroarginine methyl ester. A similar increase in systolic blood pressure was observed in both Tg2576 and control mice; however Tg2576 mice developed signs of stroke with a markedly shorter latency. Cerebral deposition of amyloid beta promotes the hypertension-induced ICH, thus supporting the notion that hypertension is a risk factor for ICH among patients with CAA.

• Authors: Giselle F Passos, Kelley Kilday, Daniel L Gillen, David H Cribbs, Vitaly Vasilevko
• Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 36 Issue 2 Pg. 399-404 (Feb 2016) ISSN: 1559-7016 [Electronic] United States
• PMID: 26661173 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2015.

Chemical References

• Amyloid beta-Peptides
• Angiotensin II
• NG-Nitroarginine Methyl Ester

Topics

• Alzheimer Disease (genetics, pathology)
• Amyloid beta-Peptides (metabolism)
• Angiotensin II (pharmacology)
• Animals
• Blood Pressure (drug effects)
• Brain (pathology)
• Cerebral Amyloid Angiopathy (complications, pathology)
• Female
• Humans
• Hypertension (complications, pathology)
• Intracranial Hemorrhage, Hypertensive (etiology, pathology)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• NG-Nitroarginine Methyl Ester (pharmacology)
• Risk Factors
• Stroke (etiology, pathology)