Abstract | BACKGROUND: The frequency of lethal overdose due to prescription and non-prescription drugs is increasing in North America. The aim of this study was to estimate overall and regional variation in incidence and outcomes of out-of-hospital cardiac arrest due to overdose across North America. METHODS: RESULTS: Included were 56,272 cases, of which 1351 were due to overdose. Regional incidence of out-of-hospital cardiac arrest due to overdose varied between 0.5 and 2.7 per 100,000 person years (p<0.001), and proportion of the same among all treated out-of-hospital cardiac arrests ranged from 0.8% to 4.0%. Overdose cases were younger, less likely to be witnessed, and less likely to present with a shockable rhythm. Compared to non-overdose, overdose was directly associated with return of spontaneous circulation (OR: 1.55; 95% CI: 1.35-1.78) and survival (OR: 2.14; 95% CI: 1.72-2.65). CONCLUSIONS: Overdose made up 2.4% of all out-of-hospital cardiac arrest, although incidence varied up to 5-fold across regions. Overdose cases were more likely to survive than non-overdose cases.
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Authors | David D Salcido, Cesar Torres, Allison C Koller, Aaron M Orkin, Robert H Schmicker, Laurie J Morrison, Graham Nichol, Shannon Stephens, James J Menegazzi, Resuscitation Outcomes Consortium Investigators |
Journal | Resuscitation
(Resuscitation)
Vol. 99
Pg. 13-9
(Feb 2016)
ISSN: 1873-1570 [Electronic] Ireland |
PMID | 26640233
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Topics |
- Adult
- Aged
- Canada
(epidemiology)
- Cardiopulmonary Resuscitation
- Cohort Studies
- Drug Overdose
(complications)
- Female
- Humans
- Incidence
- Male
- Out-of-Hospital Cardiac Arrest
(chemically induced, epidemiology, therapy)
- Retrospective Studies
- Treatment Outcome
- United States
(epidemiology)
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